Streptozocin Diabetes Elevates all Isoforms of TGF-β in the Rat Kidney
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Streptozocin Diabetes Elevates all Isoforms of TGF-β in the Rat Kidney
Transforming growth factor beta (TGF-beta) is a major promoter of diabetic nephropathy. While TGF-beta1 is the most abundant renal isoform, types 2 and 3 are present as well and have identical in vitro effects. Whole kidney extracts were studied 2 weeks after induction of streptozocin diabetes and in control rats. Mean glomerular area was 25% greater in the diabetic animals. TGF-beta1 showed a ...
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ژورنال
عنوان ژورنال: International Journal of Experimental Diabetes Research
سال: 2001
ISSN: 1560-4284
DOI: 10.1155/edr.2001.55